Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA
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چکیده
منابع مشابه
Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most prevalent multidrug-resistant pathogens worldwide, exhibiting increasing resistance to the latest antibiotic therapies. Here we show that the triple β-lactam combination meropenem-piperacillin-tazobactam (ME/PI/TZ) acts synergistically and is bactericidal against MRSA subspecies N315 and 72 other clinical MRSA isolates in vit...
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Bacterial infections remain the leading killer worldwide which is worsened by the continuous emergence of antibiotic resistance. In particular, methicillin-sensitive (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) are prevalent and the latter can be difficult to treat. The traditional strategy of novel therapeutic drug development inevitably leads to emergence of resistant strains...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2015
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.1911